The first novel ever written on a typewriter was Life on the Mississippi of Mark Twain.

Mark Twain's 1883 book, "Life on the Mississippi," was the first literary work to be completed on the machine, according to scholars.

Mark Twain claimed in his autobiography that he was the first important writer to present a publisher with a typewritten manuscript, for The Adventures of Tom Sawyer (1876). But
research showed that Twain's memory was incorrect and that the first book submitted in typed form was Life on the Mississippi (1883, also by Twain).