(A/N: This version of the arc will be in Wayne's POV. Gwen (E-199999)'s POV will be in Run Like Hell II.)

Grant Gustin as Wayne Russell/Ghost Spider (Earth-1610)

Shameik Moore as Miles Morales/Spider-Man (Earth-1610)

Hailee Steinfeld as Gwen Stacy/Spider-Woman (Earth-65)

Kelly Marie Tran as Cindy Moon/Silk (Earth-12131)

Jason Schwartzman as Dr. Jonathan Ohnn/The Spot

Oscar Isaac as Miguel O'Hara/Spider-Man 2099 (Earth-928)

Issa Rey as Jessica Drew/Spider-Woman (Earth-404)

Jake Johnson as Peter B. Parker/Spider-Man (Earth-616)

Karan Soni as Pavitr Prabhakar/Spider-Man India (Earth-50101)

Daniel Kaluuya as Hobie Brown/Spider-Punk (Earth-138)

Milly Alcock as Gwen Stacy-de Luca/ Ghost Spider (Earth-199999)

And the rest of the cast as their respective characters