OTP(S)!
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Moxiety (Sanders Sides)
Prinxiety (Sanders Sides)
Logicality (Sanders Sides)
Poly Sanders/LAMP (Sanders Sides)
Logan X Virgil (Sanders Sides)
Sandart (Thomas Sanders)
Septiplier (Jacksepticeye X Markiplier)
Antiplier (Antisepticeye X Darkiplier)
Joan X Talyn (Thomas Sanders? (They are his friends.))
Veronica X Heather Chandler (Heathers, musical and movie)
Veronica X JD (Heathers, musical and movie)
Ram X Kurt (Heathers, musical and movie)
Heater Chandler X Heather McNamera (Heathers: The Musical)
Boyf Riends (Be More Chill)
RichJake (Be More Chill)
Expensive Headphones (Be More Chill)
Tree Bros (Dear Evan Hansen)
Pidge X Shiro (Voltron)
Matt X Shiro (Voltron)
Klance (Voltron)
Shallura (Voltron)
BillDip (Gravity Falls)
Starco (Star VS The Forces Of Evil)
London X America (Hetalia)
Prussia X Canada (Hetalia)
Italy X Germany (Hetalia)
Sockathan (Welcome To Hell)
Aarmau (Aphmau)
Garrance (Aphmau)
Lucikim (Aphmau) /This is Lucinda X Kim, lol/

These are only a few that come to mind ;P