When deciding which location to go to, you will be prompted to pick a difficulty to play on.
The higher the difficulty - the greater the risk, XP, and money earned in succession.

Amateur
(Easy)
• Long setup time/hunt grace period
• Short hunt duration
• Sanity pills restore a lot of sanity
• Regain half of equipment value if you die

Intermediate
(Medium)
• Average setup time/hunt grace period/hunt duration
• Sanity pills restore some sanity
• Fuse box (power) starts off
• Fewer places to hide
• Regain some of equipment value if you die

Professional
(Hard)
• Ghost's room can rarely change
• No setup time
• Short hunt grace period
• Long hunt duration
• Sanity pills restore little sanity
• Fuse box (power) starts off
• Even fewer places to hide

Nightmare
(Very Hard)
• Ghosts only reveal two evidence
• Ghost's room will sometimes change
• No setup time
• Short hunt grace period
• Long hunt duration
• Players killed increases hunt duration
• Sanity pills restore even less sanity
• Fuse box (power) starts off
• Almost no places to hide