Lizzie is a lizard monster and is usually depicted as the second of three main protagonists, the other two being George and Ralph. In the original game, Lizzie was a woman who became mutated while swimming in a lake nearby, discarded radioactive waste, turning into a giant lizard/dinosaur as a result. Coincidentally, George and Ralph also became mutated into giant monsters. They saw each other as alike in every way, rather than monstrous abominations that normal humans saw them to be. Though her origin in World Tour is changed to be that of a scientist involved an experiment gone wrong.

Tier: 8-C |At least 8-C

Classification: Lizard, Dinosaur

Powers and Abilities: Superhuman physical characteristics, flight (Can flap her arms quick enough to fly out of Earth's orbit), large size (Type 1), fire manipulation and breath attack (Via fire breath), sound manipulation (Via the Death breath power-up), healing (Via egg consumption), transformation (Can turn into V.E.R.N. if she consumes radiation), self-sustenance (Type 1) and resistance to radiation |Superhuman physical characteristics, flight (Has wings in this form), large size (Type 1), fire manipulation and breath attack, self-sustenance (Type 1) and resistance to radiation

Attack Potency: Building level (Comparable to other mutants, such as Boris, George, and Ralph, and can one-shot tanks)|At least Building level (Stronger than before)

Speed: Superhuman normally (Can keep pace with most vehicles), Massively Hypersonic+ in Rampage Universal Tour (Comparable to Ralph)|Superhuman

Lifting Strength: Class 100 (Can easily lift and throw tanks and buses dozens of meters away)|Class 100

Striking Strength: Building level|At least Building level

Durability: Building level (Able to tank explosives, has tank machine gun fire, can shrug off tank rounds and various explosion, can take energy blasts from futuristic alien mechs, tanks being hit from her fellow mutations, tanks being electrocuted and being set on fire, shrugged off a lightning strike implied to be from God)|At least Building level

Stamina: Very high |Very high

Range: Several meters physically up to tens of meters with ranged attacks|Several meters physically, tens of meters with fire breath

Standard Equipment: None notable

Intelligence: Below Average (Despite being once human, hasn't shown much strategy other than eating and destroying)|Below Average

Weakness: Enough damage turns her back into a human|Is unable to use other power ups while in this form.

Notable Attacks and Techniques:

•Death Breath: Lizzie unleashes a loud roar that bursts up parts of buildings via sound alone.

•Fire Breath: Can exhale a stream of fire.

•V.E.R.N: A mutation that Lizzie gains via consuming radioactive waste.