One Earth Society: Composed of various villains, especially the former Regime members, the Society seeks to fill the void left by the defeated Regime. They are in odds with the Regime Remnants who seek to return to power, and the Insurgency which seeks to prevent both groups from conquering the world.

Brainiac: The responsible for the destruction of Krypton, Brainiac sets his sights on Earth and seeks to assimilate it and kill Superman once and for all.

Brainiac 8: Daughter of Brainiac, she seeks to help his father in his mission, but behind the apparently emotionless coluan, there is a human soul struggling to break free.

Atrocitus: Leader of the Red Lantern Corps. He seeks to unleash anger towards the entire universe and turn Hal Jordan into a Red Lantern.

Grid: The other side of Cyborg seeks to destroy the original Cyborg in order to show that he is the perfect being alive.

Johann Schmidt/Red Skull: Johann Schmidt was believed to have been dead once Sarah Rogers/Captain America sacrificed herself to successfully stop his plan. But he survived and finds out that his archenemy has a son. Now he intends to kill the boy who became a superhero named Super Soldier.