Claudia Scott: Joss Stone

Nathan Scott: James Lafferty

Lucas Scott: Chad Michael Murray

Haley James Stone: Bethany Joy Lenz

Peyton Sawyer: Hilarie Burton

Brooke Davis: Sophia Bush

Jack Stone: Aaron Johnson

Mouth McFadden: Lee Noris

Skills Taylor: Antwon Tanner

James Lucas Scott: Jackson Brundage 

Grace May Scott: Sabrina Carpenter