Kim Possible vs Totally Spies

Connection:

Both are redheaded high school teenagers who lived a normal life until they were turned into spies (Kim and Ron were accidentally contacted by Mr. McHenry due to a typo and Sam, Alex and Clover were watched by Jerry of WOOHP and are candidates to be spies)

Both started their spy careers at age 14

Both lacked superpowers, but have defeated other superhumans and possessed versatile gadgets

Both of their skills are actually passed down from their DNA (Kim's Possible gene and Sam being of Sisterhood ancestry)

Both are leaders of their group (Team Possible and Totally Spies respectively)

Both also have rivals in high school (Bonnie Rockwaller to Kim and Dominique to Sam)

Both can still be smitten with boys despite being the most serious of their teams