Cou 12: Neu kn ve receptor & co che td cua thuoc qua receptor.

1.KN:

- Receptor là 1 tp'dai fan tu ton tai voi 1 lg joi han (.) 1 so tb' dich,co the nhan biet 1 cach dac hieu chi 1 fan tu "thong tin" tu nhien,hoac 1 tac nhan ngoai lai de gay ra 1 td sinh hoc dac hieu,la ket qua cua td tuong ho do.

- B.chat cua receptor thg' là protein.

2. Co che:

- Thuoc td truc tiep tron coc receptor cua coc chat noi sinh: n' thuoc td tron coc receptor sinh ly & thg' mang tonh dac hieu. Neu td cua thuoc len receptor jong voi chat noi sinh goi la chat dong van hay chat chu van. Neu thuoc gan vao receptor,k gay td jong chat noi sinh,trai lai,ngan can chat noi sinh gan vao receptor,gay td uc che chat dong van,dc goi la chat doi khang.

- 1 so thuoc thong qua viec gp'cac chat noi sinh (.) co the de gay td: amphetamin gp' adrenalin tren TKTW; nitrit lam gp' NO gay jon mach.

- Do do,ngoai receptor tb',cac receptor cua thuoc cun là:

+ Cac enzym chuyen hoa hoac dieu hoa cac q.tronh sinh hoo cu the bi thuoc uc che hoac hoat hoo:

. Thuoc uc che enzym: captopril uc che enzym chuyen angiotensin I k hoat tonh thành angiotesin II cu hoat tonh dung chua cao HA; coc thuoc chong viom k fai steroid uc che cyclooxygenase,làm jam tong hop prostaglandin non cu td ha sot,chong viom; thuoc tro tim digitalis uc che Na+-K+ATPase...

. Thuoc hoat hoa enzym: cac yeu tovi lg nhu: Mg++,Cu++,Zn++ hoat hoo n' enzym protein kinase,phosphokinase td lon n' q.tronh chuyen hoo cua tb'.

- Cac ion: thuoc gan vao cac kenh ion,lam thay doi su vc ion qua mang tb'. Novocain can tro Na+ nhap vao tb' TK, ngan can khu cuc nen co td gay te; benzodiazepin lam tang nhap Cl- vao tb',gay an than.