The first season is called Futari Wa Pretty Cure or Pretty Cure in English.

The story revolves around two girls, Nagisa Misumi and Honoka Yukishiro, who fights the forces of the Dotsuku Zone - a dimension of evil that encroached on the Garden of Light. The Dotsuku Zone's power takes the form of the Zakenna, creatures that infect people or items to turn them evil.

Story:

  The Dotsuku Zone's actions necessitated the escape of two of the Garden of Light's protectors, odd talkative creatures name Mepple and Mipple. They serve as a source of information and peanut gallery for the series and are usually found within Card Communes,transformation devices which resemble mobile phones. For some periods, they can transform into their real selves and interact more easily with each other.

  The initial run of the series has Cure White and Cure Black searching for the Prism Stones,which they collect in a heart shaped device known as the Prism Hopish.The Prism Hopish is protected by the Guardian, Wisdom. Once they have collected all of the Prism Stones, their power takes them to the Garden of Light and repairs most of the damage.  

Cures:

Misumi Nagisa (美墨なぎさ Misumi Nagisa) (Natalie "Nat" Blackstone in US dub) Nagisa is the athletic heroine of the series. She is a member of the school's lacrosse team and is very popular. Although she is bad at school and is immature, she has her own sense of justice and never lets anyone dear to her down. Her alter ego is Cure Black (キュア・ブラック Kyua Burakku), with her special abilities lying in her great physical strength and prowess.

Yukishiro Honoka (雪城ほのか Yukishiro Honoka) (Hannah Whitehouse in the English dub): Honoka is the best student in the class, and loves reading books and science. Though popular with the boys, she has no interest in them. She had a special bond with Kiriya,  helping to teach him the virtues of kindness and friendship. The friends that she has are very close to her, and she will do everything to protect them. She has a lot of hope and can always see the good in people. Her alter ego is Cure White (キュア・ホワイト Kyua Howaito), with her abilities lying in her vast intelligence and agility. 

Mascots

Mepple (メップル Meppuru): He is the chosen protector of the Princess of Hope, and is in Nagisa's care. He is quite arrogant and constantly argues with with his care-taker, but he loves Mipple, and they are often seen having a "lovey-dovey" relationship. He ends his sentences with "-mepo" in the Japanese episodes. 

Mipple (ミップル Mippuru): The Princess of Hope, and also in Honoka's care. Unlike Mepple, she is reserved and seems to get along well with her care-taker, but she still cares very much for him. She ends her sentences with "-mipo" in the Japanese episodes. 

Pollun (ポルン Porun):The Prince of Light who is sent to be with Pretty Cure in the second half of the series. He is extremely selfish and usually only thinks of himself. He lives with Nagisa and annoys her and Mipple to a great extend. He ends his sentences with "-popo" in the Japanese episodes.

Dotsukku Zone

Pisard (ピーサード Pīsādo) (Pijard in the English dub): The first denizen of the Dotsuku Zone. He mainly uses his Zakenna to possess daily objects for use in fighting Pretty Cure. His prism stone was green 

Gekidrago (ピーサード Pīsādo) (Pijard in the English dub): The first denizen of the Dotsuku Zone. He mainly uses his Zakenna to possess daily objects for use in fighting Pretty Cure. His prism stone was green 

Poisony (ポイズニー Poizonī) (Pandora in the English dub): The only female of the Denizens, Poisony is the third of them. She is much more sly and careful than the others, and usually transforms into a human to gain Pretty Cure's trust first. Unlike the others she summons Zakenna by clicking her fingers. She has a younger brother, Kiriya. Her prism stone was orang 

Kiriya (キリヤ Kiriya) (Kirea in the English dub): The youngest and fourth of the denizens, and Poisony's little brother. He is arrogant and thinks of himself as being better than the others. He was sent to the Garden Of Rainbows to spy on Nagisa and Honoka but fails because of Honoka's kindness and relationship with him. His prism stone was yellow. 

IIkubo (イルクーボ Irukūbo): The last and strongest of the denizens, emotionless Illkubo can be considered the Evil King's right hand man. His prism stone was purple.

Seeds Of Darkness

Belzei Gertrude (ベルゼイ・ガートルード Beruzei Gātorūdo): One of the Seeds of Darkness that appears in the second half of the series. He is a plotter and a sadist. His human alias is Yuuki Hidehiko (ゆうき ひでひこYuuki Hidehiko). 

Regine (レギーネ Regīne): The only female of the Seeds of Darkness. As a human, she has much lower confidence than when she is in her real form. Her human alias is Koyama Shouko (こやま しょうこ Koyama Shouko). 

Juna (ジュナ Jyuna): The tall young man of the trio. More the muscle of the group, Juna is quite stoic and his expression seldom changes. His human alias is Kazukawa Ryuuichirou (かくざわ りゅういちろう Kazukawa Ryuuichirou) 

Zakeena (ザケンナー Zakennā): The physical form of the Dotsuku Zone's power. They infect items or people's shadows to turn them evil mascots. 

Evil King (ジャアクキング Jākukingu): The imprisoned ruler of the Dotsuku Zone, and also the series' main antagonist. He is made of darkness and has red glowing eyes. He wants the Prism Stones to prevent the power to consume all things to consume himself, and to gain immortality to destroy all worlds. 

Wisdom (ウィズダム Wizudamu): Wisdom is the mysterious guardian of the Prism Stones who usually appears when summoned by the Pretty Cure and who's name is only mentioned once by Iikubo. He usually hides between dimensions to guard the stones.   

Queen (クイーン Kuīn): The queen of the Garden of Light. She is a grand woman, whose height is only rivaled by that of the Evil King. She is always seen sitting on her throne with closed eyes, never moving even if she is talking. 

Elder (長老 Chōrō): A wise sage who resides in the Garden of Light. Despite his wisdom, he often keeps forgetting Nagisa and Honoka's names and referring to them as the Pretty Cura. 

Others from the Garden of Rainbows

Rina Takashimizu (高清水 莉奈 Takashimizu Rina): One of Nagisa's best friends. She is the trio's wisest when she needs to be, and is also the defense of the lacrosse team.
 

 Shiho Kubota (久保田志穂 Kubota Shiho) (Shauna in the English dub): The other friend of Nagisa. Out of the trio, she is the most hyper one, and can often be heard repeating certain words three times.
 

 Yoshimi Takenouchi (吉見竹之内 Takenouchi Yoshimi) (Yvette Woodgrove in the English dub): The teacher of Verone Academy's Cherry Blossom class. Though strict at times, she has a good heart and close relationship with her students.

Shougo Fujimura (藤村省吾 Fujimura Shougo) (Shawn Ferguson in the English dub): Honoka's childhood friend, whom Nagisa has had a crush on from before the series' start. Although nice and cheerful at all times, he does not catch Nagisa's hints. Though he does not like it, friends call him Fujipi (藤P Fujipi) (Fergie in the English dub). 

Kimata (木全 Kimata) (Kossner in the English dub): Shougo's best friend who is also part of the football team. He seems to know about Nagisa's crush on Shougo. 

Akane Fujita (藤田 アカネ Fujita Akane) (Alex in the English dub): Former lacrosse captain when she was a Verone Academy student, she now owns a mobile takoyaki shop that Nagisa, Honoka and their friends frequently visit. 

Yumiko Nakagawa (中川弓子 Nakagawa Yumiko) (Nickie in the English dub): The present captain of the lacrosse team and a senior student. 

The Principal (校長先生 Kōchō sensei): The principal of Verone Academy. Though he may look strict, he is actually very calm and slightly goofy. 

Kyouto Kometsuki (米槻教頭 Kometsuki Kyouto) (Mr. Weaver in the English dub): The vice-Principal of Verone Academy, and tries desperately to be on the principal's good side, following him everywhere. 

Items

Card Communes- The device that allows the pair to transform into their Pretty Cure forms. 

Pretty Cure Rainbow Bracelets- A power-up received later in the series that lets them use Pretty Cure Rainbow Storm.

Pretty True Love Detector- A magical device that can be used to measure the compatibility between two people or animals.

Pretty Commune- The form that Pollun takes in the Garden of Rainbows.

Prism Hopish- Is the Garden of Light's source of power, and also the source of light in the whole universe.